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University of Galway researchers have developed a modular approach to the design of cancer vaccine

Researchers at the University of Galway have created a modular method for vaccine synthesis, which might pave the way for the pioneering manufacturing of a novel cancer vaccine.

The study, which was published in the Journal of the American Chemical Society, was a partnership between laboratories in Ireland, Germany, Sweden, the Netherlands, Spain, and the United States. The study proposes a unique technique with implications for vaccine development.

The vaccine is made up of three separate components that can be put together like Legos. The first is a targeting component, a glycocluster, which selectively delivers and increases vaccine absorption into immune system cells. In order to develop long-term immunity, the second component is a T-helper epitope. The third component is a cancer T-antigen-containing molecule (MUC-1) that stimulates the immune system to create immunity against cancer-associated antigens located on the cell surfaces of breast tumours.

Dr. Adele Gabba conducted the majority of the research as a PhD student at the University of Galway, under the direction of Professor Paul Murphy, and afterwards as a postdoctoral fellow in the laboratory of Professor Pol Besenius at the Johannes Gutenberg University of Mainz, Germany.

“I am enormously grateful to all the collaborators for all their contributions,” stated Professor Paul Murphy, established professor of chemistry at the University of Galway and SFI investigator.

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